Dengue can show Hippocampal involvement & other neurological manifestations

• Hippocampal involvement in dengue fever

Singapore Med J 2005 Nov;46(11):647-50.

Authors report a 25-year-old man with dengue fever complicated by selective hippocampal involvement manifesting as amnesia. This has not been described in the literature previously. Dengue polymerase chain reaction and serology were positive. Magnetic resonance imaging of the brain showed bilateral hippocampal involvement.

• Preferential gray matter involvement in dengue myelitis.

Neurology 2004 Nov 23;63(10):1980-1

• Unusual neurologic manifestations occurring during dengue fever infection.

Am J Trop Med Hyg 1993 Jun;48(6):793-802.

The first patient developed a focal subarachnoid hemorrhage that was associated with transient thrombocytopenia. No neurologic vascular malformation was detected; a mild dengue hemorrhagic fever after a previous dengue infection was suspected. The second patient showed peripheral facial palsy one week after apyrexia without any other etiology except the dengue infection. This case was probably a postinfectious syndrome associated with dengue virus. Both patients recovered spontaneously.

• Hemorrhagic encephalopathy in dengue shock syndrome: a case report.

Braz J Infect Dis 2005 Jun;9(3):257-61. Epub 2005 Oct 3.

Dengue fever is the most important arboviral infection in the world, with an estimated 100 million cases per year and 2.5 billion people at risk. Encephalopathy is a rare complication of dengue virus infection and may occur as a consequence of intracranial hemorrhage, cerebral edema, hyponatremia, cerebral anoxia, fulminant hepatic failure with portosystemic encephalopathy, microcapillary hemorrhage or release of toxic products.