Tissue Plasminogen Activator Helpful in Acute Stroke
A reevaluation of the National Institute of Neurological Disorders and Stroke data confirms the benefit of intravenous tissue plasminogen activator for the acute management of ischemic stroke.
Pearls for Practice
T-PA treatment within NINDS protocol guidelines within three hours of acute ischemic stroke presentation is associated with a favorable outcome at three months (OR, 2.1) compared with placebo.
Less favorable outcome for t-PA is associated with older age, increasing stoke severity, history of diabetes, and preexisting disability.
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