The tree-in-bud sign is a finding seen on thin-section computed tomographic images of the lung . Peripheral, small, centrilobular, and well-defined nodules of soft-tissue attenuation are connected to linear, branching opacities that have more than one contiguous branching site, thus resembling a tree in bud. The tree-in-bud sign has primarily been used as a descriptive term for abnormalities found on CT scans of the lung in patients with endobronchial spread of Mycobacterium tuberculosis.
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